Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial
Identifieur interne : 000084 ( France/Analysis ); précédent : 000083; suivant : 000085Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial
Auteurs : A. Gori [Italie] ; G. Rizzardini [Italie] ; B. Van'T Land [Pays-Bas] ; K B Amor [Pays-Bas] ; J. Van Schaik [Pays-Bas] ; C. Torti [Italie] ; T. Quirino [Italie] ; C. Tincati [Italie] ; A. Bandera [Italie] ; J. Knol [Pays-Bas] ; K. Benlhassan-Chahour [France] ; D. Trabattoni [Italie] ; D. Bray [France] ; A. Vriesema [Pays-Bas] ; G. Welling [Pays-Bas] ; J. Garssen [Pays-Bas] ; M. Clerici [Italie]Source :
- Mucosal Immunology [ 1933-0219 ] ; 2011.
Abstract
Intestinal mucosal immune system is an early target for human immunodeficiency virus type 1 (HIV-1) infection, resulting in CD4+ T-cell depletion, deterioration of gut lining, and fecal microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides/long chain fructooligosaccharides/pectin hydrolysate-derived acidic oligosaccharides (scGOS/lcFOS/pAOS) daily) or a placebo for 12 weeks. Microbiota composition improved significantly with increased bifidobacteria, decreased
Url:
DOI: 10.1038/mi.2011.15
PubMed: 21525866
PubMed Central: 3158294
Affiliations:
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Gnocchi Foundation IRCCS</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21525866</idno><idno type="pmc">3158294</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158294</idno><idno type="RBID">PMC:3158294</idno><idno type="doi">10.1038/mi.2011.15</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000004</idno><idno type="wicri:Area/Pmc/Curation">000004</idno><idno type="wicri:Area/Pmc/Checkpoint">000344</idno><idno type="wicri:Area/Ncbi/Merge">000098</idno><idno type="wicri:Area/Ncbi/Curation">000098</idno><idno type="wicri:Area/Ncbi/Checkpoint">000098</idno><idno type="wicri:doubleKey">1933-0219:2011:Gori A:specific:prebiotics:modulate</idno><idno type="wicri:Area/Main/Merge">000A43</idno><idno type="wicri:Area/Main/Curation">000A41</idno><idno type="wicri:Area/Main/Exploration">000A41</idno><idno type="wicri:Area/France/Extraction">000084</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial</title><author><name sortKey="Gori, A" sort="Gori, A" uniqKey="Gori A" first="A" last="Gori">A. Gori</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Infectious Diseases, Department of Internal Medicine, “San Gerardo” Hospital, University of Milano-Bicocca</institution>, Monza,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rizzardini, G" sort="Rizzardini, G" uniqKey="Rizzardini G" first="G" last="Rizzardini">G. Rizzardini</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Infectious Diseases and Tropical Medicine, “Luigi Sacco” Hospital</institution>, Milan<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van T Land, B" sort="Van T Land, B" uniqKey="Van T Land B" first="B" last="Van'T Land">B. Van'T Land</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Division of Pharmacology, University of Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Amor, K B" sort="Amor, K B" uniqKey="Amor K" first="K B" last="Amor">K B Amor</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Schaik, J" sort="Van Schaik, J" uniqKey="Van Schaik J" first="J" last="Van Schaik">J. Van Schaik</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Torti, C" sort="Torti, C" uniqKey="Torti C" first="C" last="Torti">C. Torti</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Clinic of Infectious Diseases, University of Brescia</institution>, Brescia,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Quirino, T" sort="Quirino, T" uniqKey="Quirino T" first="T" last="Quirino">T. Quirino</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Infectious Diseases Unit, Busto Arsizio Hospital</institution>, Busto Arsizio,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tincati, C" sort="Tincati, C" uniqKey="Tincati C" first="C" last="Tincati">C. Tincati</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Internal Medicine, Clinic of Infectious Diseases, “San Paolo” Hospital, University of Milan</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bandera, A" sort="Bandera, A" uniqKey="Bandera A" first="A" last="Bandera">A. Bandera</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Division of Infectious Diseases, Department of Internal Medicine, “San Gerardo” Hospital, University of Milano-Bicocca</institution>, Monza,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knol, J" sort="Knol, J" uniqKey="Knol J" first="J" last="Knol">J. Knol</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benlhassan Chahour, K" sort="Benlhassan Chahour, K" uniqKey="Benlhassan Chahour K" first="K" last="Benlhassan-Chahour">K. Benlhassan-Chahour</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>ImmunoClin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Trabattoni, D" sort="Trabattoni, D" uniqKey="Trabattoni D" first="D" last="Trabattoni">D. Trabattoni</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Chair of Immunology, DISP LITA Vialba, University of Milan</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bray, D" sort="Bray, D" uniqKey="Bray D" first="D" last="Bray">D. Bray</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>ImmunoClin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vriesema, A" sort="Vriesema, A" uniqKey="Vriesema A" first="A" last="Vriesema">A. Vriesema</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Welling, G" sort="Welling, G" uniqKey="Welling G" first="G" last="Welling">G. Welling</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Department of Medical Microbiology, University Medical Center Groningen</institution>, Groningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Garssen, J" sort="Garssen, J" uniqKey="Garssen J" first="J" last="Garssen">J. Garssen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Danone Research–Centre for Specialised Nutrition</institution>, Wageningen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Division of Pharmacology, University of Utrecht</institution>, Utrecht,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clerici, M" sort="Clerici, M" uniqKey="Clerici M" first="M" last="Clerici">M. Clerici</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Biomedical Sciences and Technologies, University of Milan, and Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation IRCCS</institution>, Milan,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Mucosal Immunology</title><idno type="ISSN">1933-0219</idno><idno type="eISSN">1935-3456</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Intestinal mucosal immune system is an early target for human immunodeficiency virus type 1 (HIV-1) infection, resulting in CD4<sup>+</sup> T-cell depletion, deterioration of gut lining, and fecal microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides/long chain fructooligosaccharides/pectin hydrolysate-derived acidic oligosaccharides (scGOS/lcFOS/pAOS) daily) or a placebo for 12 weeks. Microbiota composition improved significantly with increased bifidobacteria, decreased <italic>Clostridium coccoides/Eubacterium rectale</italic> cluster, and decreased pathogenic <italic>Clostridium lituseburense</italic>/<italic>Clostridium histolyticum</italic> group levels upon prebiotic supplementation. In addition, a reduction of soluble CD14 (sCD14), activated CD4<sup>+</sup>/CD25<sup>+</sup> T cells, and significantly increased natural killer (NK) cell activity when compared with control group were seen in the treatment group. The results of this pilot trial highly significantly show that dietary supplementation with a prebiotic oligosaccharide mixture results in improvement of the gut microbiota composition, reduction of sCD14, CD4<sup>+</sup> T-cell activation (CD25), and improved NK cell activity in HAART-naive HIV-infected individuals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brenchley, J M" uniqKey="Brenchley J">J.M. Brenchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehandru, S" uniqKey="Mehandru S">S. Mehandru</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guadalupe, M" uniqKey="Guadalupe M">M. Guadalupe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, J M" uniqKey="Brenchley J">J.M. Brenchley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dandekar, S" uniqKey="Dandekar S">S. 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Abee</name></author><author><name sortKey="De Vos, W M" uniqKey="De Vos W">W.M. de Vos</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Italie</li><li>Pays-Bas</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Gori, A" sort="Gori, A" uniqKey="Gori A" first="A" last="Gori">A. Gori</name></noRegion><name sortKey="Bandera, A" sort="Bandera, A" uniqKey="Bandera A" first="A" last="Bandera">A. Bandera</name><name sortKey="Clerici, M" sort="Clerici, M" uniqKey="Clerici M" first="M" last="Clerici">M. Clerici</name><name sortKey="Quirino, T" sort="Quirino, T" uniqKey="Quirino T" first="T" last="Quirino">T. Quirino</name><name sortKey="Rizzardini, G" sort="Rizzardini, G" uniqKey="Rizzardini G" first="G" last="Rizzardini">G. Rizzardini</name><name sortKey="Tincati, C" sort="Tincati, C" uniqKey="Tincati C" first="C" last="Tincati">C. Tincati</name><name sortKey="Torti, C" sort="Torti, C" uniqKey="Torti C" first="C" last="Torti">C. Torti</name><name sortKey="Trabattoni, D" sort="Trabattoni, D" uniqKey="Trabattoni D" first="D" last="Trabattoni">D. Trabattoni</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van T Land, B" sort="Van T Land, B" uniqKey="Van T Land B" first="B" last="Van'T Land">B. Van'T Land</name></noRegion><name sortKey="Amor, K B" sort="Amor, K B" uniqKey="Amor K" first="K B" last="Amor">K B Amor</name><name sortKey="Garssen, J" sort="Garssen, J" uniqKey="Garssen J" first="J" last="Garssen">J. Garssen</name><name sortKey="Garssen, J" sort="Garssen, J" uniqKey="Garssen J" first="J" last="Garssen">J. Garssen</name><name sortKey="Knol, J" sort="Knol, J" uniqKey="Knol J" first="J" last="Knol">J. Knol</name><name sortKey="Van Schaik, J" sort="Van Schaik, J" uniqKey="Van Schaik J" first="J" last="Van Schaik">J. Van Schaik</name><name sortKey="Van T Land, B" sort="Van T Land, B" uniqKey="Van T Land B" first="B" last="Van'T Land">B. Van'T Land</name><name sortKey="Vriesema, A" sort="Vriesema, A" uniqKey="Vriesema A" first="A" last="Vriesema">A. Vriesema</name><name sortKey="Welling, G" sort="Welling, G" uniqKey="Welling G" first="G" last="Welling">G. Welling</name></country><country name="France"><noRegion><name sortKey="Benlhassan Chahour, K" sort="Benlhassan Chahour, K" uniqKey="Benlhassan Chahour K" first="K" last="Benlhassan-Chahour">K. Benlhassan-Chahour</name></noRegion><name sortKey="Bray, D" sort="Bray, D" uniqKey="Bray D" first="D" last="Bray">D. Bray</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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